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Your order includes a FREE consultation with one of our U.S. licensed doctors! We accept major credit cards, or we can debit your bank account electronically. Your online order will be shipped via Fed-Ex upon your approval. Buy Skelaxin online from our online pharmacy.
Uses
Skelaxin relaxes certain muscles and relieves pain caused by muscle injuries, sprains, and strains. Belongs to the group of drugs called muscle relaxants. Take Skelaxin exactly as your doctor ordered. May be taken with or without food.
How To Use
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.Make sure your doctor knows if you are taking other drugs that could make you sleepy such as sleeping pills, cold or allergy medicine, other muscle relaxants, tranquilizers, narcotic pain killers or antidepressants. Do not drink alcohol while taking Skelaxin. Side Effects
Call your doctor right away if you have any of these side effects:Fast or irregular heartbeat Wheezing or trouble breathing Skin rash, severe itching or hives Swelling of the face, eyelids, mouth, or lips Unusual bruising or bleeding Unexplained fever or sore throat Yellowing of the skin or eyesIf you have problems with these less serious side effects, talk with your doctor.Nausea or vomiting Dizziness, drowsiness, or confusion Headache, nervousness, or irritability Stomach upset or heartburn Diarrhea or constipation Blurred vision Precautions
Check with your doctor before taking Skelaxin if you have blood, kidney, or liver disease, or seizures. If you are pregnant or breastfeeding, talk with your doctor before taking Skelaxin. Skelaxin may make you drowsy or dizzy. Be careful if you are driving a car or using machinery. Metaxalone may affect the results tests that checks for sugar in the urine of patients with diabetes. If you have diabetes don't make any changes in your medicine or diet unless you have checked with your doctor. Notes
You should not use Skelaxin if you have had an allergic reaction to metaxalone. Missed Dose
Take the missed dose as soon as possible if it is within 1 hour of your regular dosing time. If it is almost time for your next regular dose, skip the missed dose and take your medicine at your usual times. You should not use two doses at the same time. Storage
Store at room temperature, away from heat, moisture, and direct light. Keep all medicine out of the reach of children.
Disclaimer
This online drug information on Skelaxin is for your information purposes only. It is not intended to covers all uses, occasions, directions, drug interactions, precautions, or adverse effects of your Skelaxin medication. This online Skelaxin medication information is only a general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions on Skelaxin medication for any particular patient. We disclaim all responsibilities for the accuracy and reliability of this information, and/or any consequences arising from the use of this information pertaining to Skelaxin (and any other drug information on all web pages in this web site) including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.
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Skelaxin or metaxalone Refs
Skelaxin
Comparison of the dissolution of metaxalone tablets (Skelaxin) using USP Apparatus 2 and 3.
Cacace J, Reilly EE, Amann A.
Nova Southeastern University, College of Pharmacy, 3200 South University Drive, Ft Lauderdale, FL 33328-2018, USA. jcacace nova.edu
The purpose of this study was to evaluate the effect of pH on the dissolution behavior of metaxalone in the marketed product Skelaxin tablets. The dissolution was evaluated using United States Pharmacopeia (USP) dissolution Apparatus 2 and 3 at pHs ranging from 1.5 to 7.4. Results from these studies show that the dissolution of this product is pH dependent. At low pH (simulated gastric fluid, pH 1.5), the dissolution of metaxalone from Skelaxin tablets was less than 10% over 75 minutes; whereas, dissolution at pH 4.5 showed greater than 90% release in the same time period. These results were consistent for both Apparatus 2 and 3. This suggests that Skelaxin Tablets should be considered a delayed release dosage form.
Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15198527&dopt=Abstract metaxalone Skelaxin
Skelaxin
A fatality involving metaxalone.
Moore KA, Levine B, Fowler D.
Office of the Chief Medical Examiner, State of Maryland, 111 Penn St., Baltimore, MD, 21201, USA.
A case is presented of a 54-year-old white female found dead in a secured apartment. Postmortem toxicologic analysis of the heart blood identified acetaminophen (97mg/L), citalopram (0.4mg/L), gabapentin (24mg/L) and metaxalone (21mg/L). The metaxalone concentration is within the range of previously reported fatalities involving metaxalone. The medical examiner ruled that the cause of death was metaxalone and gabapentin intoxication and the manner of death was suicide.
Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15749367&dopt=Abstract metaxalone Skelaxin
Skelaxin
Cyclization-activated prodrugs: N-(substituted 2-hydroxyphenyl and 2-hydroxypropyl)carbamates based on ring-opened derivatives of active benzoxazolones and oxazolidinones as mutual prodrugs of acetaminophen.
Vigroux A, Bergon M, Zedde C.
Laboratoire de Synthese et Physicochimie Organique Associe au CNRS, Universite Paul Sabatier, Toulouse, France.
N-(Substituted 2-hydroxyphenyl)- and N-(substituted 2-hydroxypropyl)carbamates based on masked active benzoxazolones (model A) and oxazolidinones (model B), respectively, were synthesized and evaluated as potential drug delivery systems. A series of alkyl and aryl N-(5-chloro-2-hydroxyphenyl)carbamates 1 related to model A was prepared. These are open drugs of the skeletal muscle relaxant chlorzoxazone. The corresponding 4-acetamidophenyl ester named chlorzacetamol is a mutual prodrug of chlorzoxazone and acetaminophen. Chlorzacetamol and two other mutual prodrugs of active benzoxazolones and acetaminophen were obtained in a two-step process via condensation of 4-acetamidophenyl 1,2,2,2-tetrachloroethyl carbonate with the appropriate anilines. Based on model B, two mutual prodrugs of acetaminophen and active oxazolidinones (metaxalone and mephenoxalone) were similarly obtained using the appropriate amines. All the carbamate prodrugs prepared were found to release the parent drugs in aqueous (pH 6-11) and plasma (pH 7.4) media. The detailed mechanistic study of prodrugs 1 carried out in aqueous medium at 37 degrees C shows a change in the Bronsted-type relationship log t1/2 vs pKa of the leaving groups ROH: log t1/2 = 0.46pKa-3.55 for aryl and trihalogenoethyl esters and log t1/2 = 1.46pKa-16.03 for alkyl esters. This change is consistent with a cyclization mechanism involving a change in the rate-limiting step from formation of a cyclic tetrahedral intermediate (step k1) to departure of the leaving group ROH (step k2) when the leaving group ability decreases. This mechanism occurs for all the prodrugs related to model A. Regeneration of the parent drugs from mutual prodrugs related to model B takes place by means of a rate-limiting elimination-addition reaction (E1cB mechanism). This affords acetaminophen and the corresponding 2-hydroxypropyl isocyanate intermediates which cyclize at any pH to the corresponding oxazolidinone drugs. As opposed to model A, the rates of hydrolysis of mutual prodrugs of model B clearly exhibit a catalytic role of the plasma. It is concluded from the plasma studies that the carbamate substrates can be enzymatically transformed into potent electrophiles, i.e., isocyanates. In the case of the present study, the prodrugs are 2-hydroxycarbamates for which the propinquity of the hydroxyl residue and the isocyanate group enforces a cyclization reaction. This mechanistic particularity precludes their potential toxicity in terms of potent electrophiles capable of modifying critical macromolecules.
Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7562932&dopt=Abstract metaxalone Skelaxin
Skelaxin
Pharmacological profile of N-(2,6-DIMETHYLPHENYL)-N-(1-methyl-2pyrrolidinylidene)urea, xilobam, a new centrally acting skeletal muscle relaxant.
Gardocki JF, Hageman WE, Pruss TP.
The pharmacological profile of a new centrally acting skeletal muscle relaxant, xilobam, is described and compared to that of existing skeletal muscle relaxants. The potencyof xilobam, administered intravenously, is approximately ten times that of methocarbamol in the linguomandibular assay in the cat. When evaluated in the strychnin assay in the mouse, the potency of xilobam is approximately seven times that of chlorzoxazone and eleven tomes that of methocarbamol and five times that of metaxalone. In contrast to methocarbamol, xilobam exhibits little or no sedative activity and appears devoid of antianxiety properties. When administered to non-anesthetized dogs, xilobam and other centrally acting muscle relaxants, such as chlorzoxazone and methocarbamol, increased arterial pressure and heart rate. Mydraiasis, vocalization and muscle rigidity were concomitantly observed. These effects appear to be centrally induced. It is concluded that xilobam appears to be a potent centrally acting muscle relaxant which should not be sedating or anxiolytic in man.
Online source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=99099&dopt=Abstract metaxalone Skelaxin
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