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J Pediatr Hematol Oncol. 2000 Nov-Dec;22(6):533-8.
Two cases of autoimmune neutropenia possibly induced by beta-lactam antibiotics in infants.

Taniuchi S, Masuda M, Yamamoto A, Hasui M, Tsuji S, Takahashi H, Kobayashi Y.

Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka, Japan. taniuchakii.kmu.ac.jp

This report describes two infants who had neutropenia develop after treatment with beta-lactam antibiotics. The first patient, a 9-month-old girl, was administered flomoxef (FMOX); the second patient, a 14-month-old boy, was administered cefotiam (CTM). Both infants were found to have neutropenia 4 to 5 days after they were placed on respective antibiotics, and neutropenia had persisted despite antibiotics withdrawal for 1 to 3 months. Drug-induced lymphocyte stimulation test (DLST), granulocyte-bound antibodies, serum granulocyte antibodies, and immunoblotting analysis indicated that beta-lactam antibiotics possibly triggered production of granulocyte autoantibody with resultant autoimmune neutropenia.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11132223&dopt=Abstract

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