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Folia Microbiol (Praha). 1998;43(6):683-6.
Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics.

Tejedor-Junco MT, Gonzalez-Martin M, Lupiola P, Gonzalez-Lama Z.

Departamento de Ciencias Clinicas, Microbiologia, Universidad de Las Palmas de Gran Canaria, Canary Islands, Spain.

The interaction of type-I beta-lactamases from Enterobacter cloacae with diverse beta-lactam compounds was examined. The ability of penicillin and cefoxitin to induce beta-lactamase production in this strain was assessed. The effect of beta-lactamase inhibitors was measured on beta-lactamase extracts and on intact cells. E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropriate choice for therapy of infections caused by stably derepressed mutants of Enterobacter sp. producing type-I beta-lactamases.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10069013&dopt=Abstract

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