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Ann Microbiol (Paris). 1979 Apr;130A(3):331-43.
[Comparison of bactericidal effects of four aminoglycoside antibiotics: amikacin, gentamicin, kanamycin and tobramycin (author's transl)]

[Article in French]

Drugeon HB, Courtieu AL.

The authors have studied on 20 bacterial strains (5 Pseudomonas aeruginosa, 5 Escherichia coli, 5 Klebsiella and 5 Serratia) the bactericidal kinetics of 4 aminoglycoside antibiotics: amikacin, gentamicin, kanamycin and tobramycin. The antibiotic concentrations used for this work were 1.5 times the MIC for each strain previously measured in a liquid medium. The action of the aminoglycoside antibiotics shows three phases. The third phase describes a part of less susceptible bacterial population. It permits the comparison of the 4 antibiotics. Amikacin shows the best activity, followed by gentamicin, kanamycin and tobramycin.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=114083&dopt=Abstract

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