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Recenti Prog Med. 2002 Jul-Aug;93(7-8):428-31.
[Ticlopidine-induced aplastic anemia. A case report and review of the literature]

[Article in Italian]

Bortolotti R, Savino M, Noro G.

Unita Operativa Geriatria, Ospedale Civile Santa Chiara, A.P.S.S., Trento.

Ticlopidine, an inhibitor of platelet aggregation, is widely used for peripheral arterial disease. The use of this drug has been associated with neutropenie and other adverse hematologic effects. Aplastic anemie is a rate complication that carries high mortality. We describe the case of a 91 years old woman with ticlopedine-induced aplastic anemia. The patient was treated with filgrastim brood spectrum antibiotics and other general supportive care measures. Despite initial improvement the old woman died 7 weeks after admission for septic shock. A review of medical literature revealed 24 similar cases. Filgrastim has been used previous by with variable success.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12138688&dopt=Abstract

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