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Rinsho Ketsueki. 2002 Nov;43(11):998-1003.
[Successful treatment with G-CSF and corticosteroid of adult idiopathic autoimmune neutropenia presenting as recurrent enterocolitis]

[Article in Japanese]

Fujimi A, Matsunaga T, Ohnishi R, Takemoto N, Tanaka I, Akiyama T, Sato T, Morii K, Terui T, Kogawa K, Kato J, Hirayama M, Ohmi N, Sakamaki S, Niitsu Y.

4th Department of Internal Medicine, Sapporo Medical University School of Medicine.

A 63-year-old woman had previously been admitted to another hospital due to fever, abdominal pain and diarrhea. She was treated with fasting, antibiotics and G-CSF administration because of the coexistence of neutropenia, and the symptoms improved. However, discontinuation of G-CSF administration resulted in a recurrence of the neutropenia accompanied with enterocolitis. After admission to our hospital, a diagnosis for idiopathic AIN was performed as she tested positive in both granulocyte immunofluorescence and granulocyte agglutination tests. Administration of corticosteroid following G-CSF resulted in a continuous increase in the neutrophil count and the disappearance of anti-neutrophil autoantibodies.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12508486&dopt=Abstract

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