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Fitoterapia. 2002 Jul;73(4):300-4.
The genus Hypericum--a valuable resource of anti-Staphylococcal leads.

Gibbons S, Ohlendorf B, Johnsen I.

Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. simon.gibbonlsop.ac.uk

In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 microg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12234572&dopt=Abstract








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