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Int J Antimicrob Agents. 2002 Sep;20(3):174-9.
Characterization of methicillin-resistant Staphylococcus aureus strains susceptible to tobramycin.
Talon D, Deliere E, Bertrand X.
Service d'Hygiene hospitaliere et d'Epidemiologie moleculaire, Centre Hospitalier Universitaire Jean Minjoz, Besancon 25030, France. daniel.talofc-chu.univ-fcomte.fr
Gentamicin-susceptible, methicillin-resistant, Stapylococcus aureus strains (GS-MRSA) emerged in 1992 in various Parisian hospitals and have subsequently been isolated from all French hospitals. This new GS-MRSA epidemic clone accounted for 50% of MRSA strains in 1996 and for 85% in 2000 in our hospital. We have observed a parallel increase in the prevalence of tobramycin and amikacin-susceptible GS-MRSA (TKS-MRSA). The number of TKS-MRSA strains per 100 MRSA strains has steadily increased from 3.1 in 1996 to 24.0 in 2000. Genotypic characterization of TKS-MRSA strains showed that these strains are a phenotypic variant of the dominant clone of GS-MRSA. To improve our understanding of the changes in methicillin-resistant Staphylococcus aureus (MRSA) susceptibility to non-beta-lactam antibiotics, gentamicin- and amikacin-susceptible MRSA (TKS-MRSA) from our acute-care hospital were compared with TKS-MRSA isolated from a long-term care hospital located in another region of France. The nature of the care facility did not seem to play a major role in the hospital dissemination of TKS-MRSA. We also found that changes in antibiotic use alone do not account for the emergence of these strains. 2002 Elsevier Science B.V. and International Society of Chemotherapy
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12385695&dopt=Abstract
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