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Can J Urol. 1995 May;2(2):144-7.
Fournier's gangrene: nine cases of necrotizing infection of the male genitalia.

Crofts NG, Hosking DH.

Chief Resident, Section of Urology, University of Manitoba, Winnipeg, Manitoba.

Between 1989 and 1993, nine patients with Fournier's gangrene presented to our institution. The mean patient age was 66 years. The source of infection was dermal in five cases, urethral in three cases and rectal in one case. Potential contributing factors included diabetes mellitus in six cases, alcohol abuse in four cases and drug-induces immunosuppression in two cases. In every patient, tissue cultures revealed mixed aerobic and anaerobic infections. All patients were treated initially with aggressive surgical debridement and culture-specific intravenous antibiotics. One patient required multiple debridements. Reconstruction by split-thickness skin grafts was performed in eight cases and one healed by secondary intention. There were no deaths due to progressive infection. The mortality rate was 11% with six month follow-up. The favorable outcome of patients in this series supports the current recommendation for early, aggressive surgical debridement and culture-specific, intravenous antibiotic therapy.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12803722&dopt=Abstract [PubMed]

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