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Antibiot Khimioter. 2002;47(6):38-41.
[Fibrin-collagen substance as a vehicle for local application of antibacterial agents]

[Article in Russian]

Gorskii VA, Gertsog AA, Leonenko IV, Shamanek TP, Sokov BN.

Russian State Medical University, Municipal Clinical Hospital No. 55, Moscow.

Inhibitory activity of fibrin-collagen substance (FCS) impregnated by various antibacterial agents against various microorganisms was investigated. It was demonstrated that antibacterials bind well with FCS, providing its sufficient antibacterial activity. Determination of growth-inhibition zones showed that antibacterial agents diffuse into medium well and demonstrated the same activity as discs with antibiotics. For clinical practice it is recommended to use for impregnation the following drugs: gentamycin, meropenem, cefriaxone and ciprofloxacin.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12422648&dopt=Abstract

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