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Psychiatry Clin Neurosci. 2002 Jun;56(3):295-6.
Situation and problem of administration methods and the intermission of hypnotics.
Uchimura N, Takeuchi N, Kuwahara H, Nose I, Hashizume Y, Shirakawa S, Ohyama T, Maeda H.
Department of Neuropsychiatry, Kurume University, Kurume, Fukuoka, Japan. naohised.kurume-u.ac.jp
The results of a questionnaire survey suggested four problems that might prolong the administration of benzodiazepine hypnotics without suspending the medication. First, psychiatrists did not actively consider the necessity of suspension of medication with hypnotics. Second, the period between improvement of insomnia and initiation of dose reduction was long, whereas the period between initiation of dose reduction and discontinuation was short. Third, to suspend medication of a hypnotic, every-other-day administration was used for the very short-acting and short-acting types, and substitution of the intermediate-acting or long-action type for the drugs with a short half-life were performed frequently. Finally, dose reduction and intermission of medication induced rebound insomnia, withdrawal symptoms, and recurrence of insomnia.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12047602&dopt=Abstract
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