Influence of a pre-existing phospholipidosis on the accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages. Axonal and cellular alterations in the inner ear of rats treated with chlorphentermine or iprindole. Differential influence of anionic and cationic charge on the ability of amphiphilic drugs to interact with DPPC-liposomes. Ionamin online references

Ionamin online research references

Res Commun Chem Pathol Pharmacol. 1991 May;72(2):169-81.
Influence of a pre-existing phospholipidosis on the accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages.

Reasor MJ.

Department of Pharmacology and Toxicology, West Virginia University Health Sciences Center, Morgantown 26506.

Amiodarone is an antiarrhythmic drug that concentrates in the lungs and can cause pulmonary damage in humans. The purpose of the present study was to examine the influence of a pre-existing lung pathology on the pulmonary accumulation of amiodarone and its primary metabolite, desethylamiodarone. To study this problem, male Fischer 344 rats were administered chlorphentermine to induce a phospholipidosis in the alveolar macrophages of the lungs. The accumulation of amiodarone and desethylamiodarone in phospholipidotic alveolar macrophages was measured following 5 weeks of amiodarone administration. When calculated on a per cell basis, the levels of both drugs were increased over 10-fold in phospholipid-laden macrophages compared to cells from control rats in which a phospholipidosis was not present. When phospholipidotic macrophages were exposed to amiodarone and desethylamiodarone in vitro, both drugs were accumulated to a higher level than occurred in cells from control rats. The results of this study demonstrate that the presence of a pre-existing phospholipidosis results in an enhanced accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1876748&dopt=Abstract

kwd match ionamin online literature

Virchows Arch B Cell Pathol. 1977 Jan 20;23(1):87-92.
Axonal and cellular alterations in the inner ear of rats treated with chlorphentermine or iprindole.

Drenckhahn D.

An electron-microscopic study was carried out on the inner ear of rats, which had been treated with the anorectic drug chlorphentermine and the antidepressant drug iprindole, two cationic amphiphilic compounds known to induce a generalized lipidosis. After chronic drug treatment the following vestibular and cochlear alterations were observed: a) numerous lamellated and crystalloid cytoplasmic inclusion bodies in various cell types, typical of drug-induced lipidosis; b) axonal balloonings predominantly affecting preterminal sensory endings which were filled with masses of coarse osmiophilic inclusions and autophagic vacuoles. With prolonged treatment degeneration of nerve fibers below the sensory epithelium was observed in increased numbers. Axonal changes are tentatively interpreted to result from drug-induced interference with certain catabolic processes involved in the normal degradation of axoplasmic constituents.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=190762&dopt=Abstract

kwd match ionamin online literature

Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):961-5.
Differential influence of anionic and cationic charge on the ability of amphiphilic drugs to interact with DPPC-liposomes.

Mohr K, Struve M.

Department of Pharmacology, University of Kiel, Federal Republic of Germany.

The compounds clofibric acid and chlorphentermine have identical aromatic ring systems, but when charged their side chains are anionic or cationic, respectively. The drugs were applied as tools to investigate whether the interaction of amphiphilic drugs with the zwitterionic dipalmitoyl-phosphatidylcholine (DPPC) depends on the charge of the polar side chain. In suspensions of DPPC-liposomes, the drug-effect on the phase-transition temperature (Tt) was evaluated by means of differential scanning calorimetry. The drug-binding was determined spectrophotometrically. The clofibric acid anion had a much weaker depressing effect on Tt than the chlorphentermine-cation and a considerably lower ability to bind to the DPPC-liposomes. Furthermore, a plot of the effect versus the binding suggested that the clofibric acid-anion had a lower intrinsic activity to reduce Tt compared with the chlorphentermine-cation. In contrast, when the dissociation-equilibrium was shifted towards the uncharged state both drugs were indistinguishable with respect to effect and binding, suggesting that the differences observed with the charged forms could indeed be attributed to the opposite charges. The findings are tentatively explained to result from a different ability of the anionic and the cationic form to reach the hydrophobic interior of the DPPC-bilayer.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2009087&dopt=Abstract

kwd match ionamin online literature

Dream Pharmaceuticals Rx Online Bontril
Dream Pharmaceuticals Rx Online Celebrex
Dream Pharmaceuticals Rx Online Evista

DreamPharm: Herbal and Nutritional supplements online || Hair Million herbal formula for hair loss and hair growth || Dream Pharmaceuticals Rx: Prescription Drugs Online || Tramadol Online || Paxil Online || Buspar Online || Cialis Online || Antibiotics Online Antibiotics and prescription medications online literature || E-Mail Us