Ionamin online research references
Virchows Arch B Cell Pathol. 1978 May 19;27(3):255-66.
Anterior polar cataract and lysosomal alterations in the lens of rats treated with the amphiphilic lipidosis-inducing drugs chloroquine and chlorphentermine.
Drenckhahn D.
Chronic treatment of rats with the amphipilic drugs chloroquine and chlorphentermine caused prominent anterior polar cataracts in virtually all rats. The basic pathologic changes underlying these cataracts were: (a) degeneration of anterior polar and sutural endings of cortical lens cells and (b) multilayered proliferation and invasion of epithelial cells into the anterior polar cortex. Ultrastructurally cortical lens cells displayed various patterns of degeneration, finally undergoing complete liquification. Liquified lens substance was phagocytosed by invading epithelial cells. Cortical lens cells and epithelial cells contained numerous lipidosis-like (lamellated) inclusions, which possessed cytochemical acid phosphatase activity. The present drug-induced lenticular alterations are interpreted as the direct or indirect consequences of a drug-induced disturbance of polar lipid metabolism in the lens.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=208230&dopt=Abstract
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J Pharm Sci. 1976 Jan;65(1):122-6.
Inhibition of synaptosomal accumulation of l-norepinephrine II: N-aryloxyalkylphentermines, quaternary d-amphetamines, and 3-aryloxypropylamines.
Schaeffer JC, Cho AK, Fischer JF.
The inhibitory potencies of a series of N-substituted phentermines on the synaptosomal uptake of l-norepinephrine were found to be similar to those of the corresponding amphetamines. Quaternization of N, N-dimenthyl-d-amphetamine diminished, but did not abolish, its inhibitory potency, indicating that a permanently charged cation is also effective. Since the addition of an aromatic moiety at the end of a four-atom chain originating at the nitrogen of amphetamine or phentermine significantly increased inhibitor strength, several 3-aryloxypropylamines and 4-phenylbutylamine were tested, but they were much weaker inhibitors than dl-amphetamine. Thus, the observed increase in inhibitor potency apparently was not simply the result of a specific interaction of the "nonmimic" portion of the N-substituted amphetamines or phentermines.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1255416&dopt=Abstract
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Acta Neuropathol (Berl). 1979 May 15;46(3):203-8.
Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus.
Frisch W, Lullmann-Rauch R.
Several cationic amphiphilic drugs, each of which is known to induce generalized lipidosis in rats, were compared with respect to their cytological effects on rat choroid plexus epithelium. Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4'-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis. The ultrastructure of the chloroquine-induced vacuoles suggested storage of water-soluble materials (polar lipids and/or non-lipid materials) in addition to non-water-soluble polar lipids.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=223364&dopt=Abstract
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