Effect of chlorphentermine on incorporation of [14C]choline in the rat lung phospholipids. Alterations in rat alveolar surfactant phospholipids and proteins induced by administration of chlorphentermine. Intravenous self-administration of phentermine in food-deprived rats: effects of abrupt refeeding and saline substitution. Ionamin online references

Ionamin online research references

Lipids. 1986 Mar;21(3):230-4.
Effect of chlorphentermine on incorporation of [14C]choline in the rat lung phospholipids.

Gonmori K, Morita T, Mehendale HM.

The effect of chlorphentermine (CP) treatment (50 mg/kg/day, per os [po]) on the incorporation of [14C]choline into rat lung phospholipid was studied. Total phospholipid content was increased 2.0-fold and 1.7-fold after seven and 14 days, respectively, compared with the pair-fed rats. The incorporation of [14C]choline into phosphatidylcholine (PC) was significantly inhibited by either seven or 14 days of CP treatment. Nevertheless, the PC content was significantly increased by day 7 and stayed elevated at day 14 of CP treatment. Choline and phosphorylcholine contents were significantly decreased by the CP treatment. These results suggest that the higher accumulation of PC is due to inhibition of enzymes involved in the hydrolysis of phospholipids rather than to a stimulation of the phospholipid synthesis.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3702614&dopt=Abstract

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Biochim Biophys Acta. 1986 Jun 11;877(1):167-78.
Alterations in rat alveolar surfactant phospholipids and proteins induced by administration of chlorphentermine.

Miles PR, Bowman L, Tucker J, Reasor MJ, Wright JR.

Chlorphentermine is a cationic amphiphilic drug which produces a phospholipid storage disorder in rat lungs. Experiments were carried out to characterize changes in the composition of acellular alveolar lavage materials and to study possible mechanisms by which pulmonary surfactant phospholipidosis is produced by administration of the drug. Following ten daily injections of chlorphentermine (25 mg/kg body weight), there are 12.2- and 13.6-fold increases of pulmonary lavage total phospholipids and disaturated phosphatidylcholines (disaturated PC), respectively. In addition, there is a 2.8-fold increase in total protein and a 12.7-fold increase in the surfactant apoprotein group with molecular weights from 28,000 to 32,000. We measured incorporation of labeled palmitate, choline and glycerol into disaturated PC in type II cells and alveolar macrophages isolated from control and chlorphentermine-treated animals. The drug does not affect the incorporation of labeled substrates into disaturated PC in either cell type. However, in alveolar macrophages there is a decrease in the rate of intracellular degradation of recently synthesized disaturated PC in chlorphentermine-treated animals. The drug also inhibits the phospholipase-induced catabolism of rat surfactant disaturated PC which occurs during incubation of alveolar lavage fluid in vitro at 37 degrees C. When the lavage fluid is divided into subfractions by differential centrifugation, a larger percentage of the phospholipid is distributed in the less sedimentable subfractions in chlorphentermine-treated animals relative to controls, suggesting the accumulation of older surfactant materials. These results suggest that chlorphentermine-induced phospholipidosis of pulmonary surfactant materials is due to decreased rates of phospholipid degradation.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3755061&dopt=Abstract

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Pharmacol Biochem Behav. 1986 Sep;25(3):623-7.
Intravenous self-administration of phentermine in food-deprived rats: effects of abrupt refeeding and saline substitution.

Papasava M, Singer G, Papasava CL.

The objectives in these experiments were to determine the effects on intravenous phentermine self-administration of abrupt refeeding and of saline substitution in food-deprived rats. In Experiment 1, 32 naive rats, reduced to 80% free-feeding weight (FFW), were assigned randomly to four equal-sized groups. Two groups self-administered phentermine, the other two saline over two consecutive six-day phases. In phase 1, all animals were maintained at 80% FFW, while in phase 2, one phentermine- and one saline-reinforced group was abruptly food satiated. Results showed that phentermine self-administration was suppressed. In Experiment 2, another 32 naive rats were assigned to four equal-sized groups and tested over two consecutive six-day phases. Two groups were FF, the other two were reduced to 80% FFW. In phase 1, a group of FF and 80% FFW animals self-administered phentermine, the other two saline, while in phase 2, treatments were reversed: previously phentermine-reinforced animals self-administered saline and vice versa. Findings showed that 80% FFW rats rapidly discriminate the introduction or removal of phentermine and alter responding accordingly, while FF animals respond at low rates throughout.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3774828&dopt=Abstract

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