Ionamin online research references
Laryngol Rhinol Otol (Stuttg). 1983 Nov;62(11):526-31.
[Chlorphentermine-induced lipidosis of the cochlea and the cochlear nucleus]
[Article in German]
Bichler E.
The anoretic drug chlorphentermine induces, after long-term feeding, an accumulation of phospholipids mainly stored in lysosomes. Inner hair cells and nerve running to these cells are especially affected, whereas the outer hair cells and their nerves are less changed. Supporting cells and ganglion cells of the spiral ganglion always exhibit inclusions. Changes in the perikarya of the cochlear nucleus are not so outstanding and are in the scope of the alterations found in other parts of the nervous system. The morphological alterations allow some conclusions about the phospholipid metabolism and the lysosomal capacity of the affected cells. Furthermore, experimental lipidosis is considered as an useful model for inherited lipidosis bearing in mind the different pathogenesis underlying both conditions. Last but not least, the clinical consequence has to be pointed out when treating with drugs having different main effects but the same side effects.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6318004&dopt=Abstract
kwd match ionamin online literature
Am Rev Respir Dis. 1983 Jun;127(6):747-50.
Effects of chlorphentermine and phentermine on the pulmonary disposition of 5-hydroxytryptamine in the rat in vivo.
Morita T, Mehendale HM.
This study was designed to examine whether chlorphentermine (CP) affects pulmonary disposition of 5-hydroxytryptamine (5-HT) in rat in vivo. Further, the effects of CP were compared with those of phentermine (P), the nonchlorinated congener. The right jugular vein and left carotid artery of male Sprague-Dawley rats were cannulated to the level of the superior caval vein and ascending aorta, respectively. After 10 min of stabilization, 0.3 ml fresh saline solution containing 150 micrograms indocyanine green and a mixture of labeled and unlabeled 5-HT was injected into the jugular vein, and arterial blood samples were collected for 20 s. Pulmonary extraction of 5-HT during a single pass was inversely proportional to the injected dose, ranging from 67% cf injected dose for a 2.6 nmol dose to 30% for a 130 nmol dose, indicating a saturable pulmonary uptake for 5-HT. In order to compare the effect of CP and P on pulmonary disposition of 5-HT, 2.6 nmol [14C]-5-HT was employed for in vivo single-pass experiments. Each animal was used for 2 in vivo single-pass experiments. After the first experiment, which served as a control, animals received an indicated dose of CP or P, to commence the second "drug-treated" in vivo experiment. Pulmonary clearance of 5-HT was inhibited by prior administration of CP (1 mg/kg) by 42%, whereas at the highest dose (20 mg/kg) P inhibited 5-HT clearance by only 25%. Pulmonary accumulation of CP was greater than P at higher doses, and the inhibition of 5-HT clearance correlated with the pulmonary accumulation of these drugs. In addition to the in vivo demonstration of the CP inhibition of pulmonary clearance of 5-HT in the rat, these studies also demonstrate a higher affinity of the lung tissue for CP than for P and a greater propensity for the impairment of pulmonary 5-HT clearance.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6344705&dopt=Abstract
kwd match ionamin online literature
Methods Find Exp Clin Pharmacol. 1984 May;6(5):265-70.
Comparison of the acute physical and mental effects of ephedrine, fenfluramine, phentermine and prolintane.
Kuitunen T, Karkkainen S, Ylitalo P.
Physical and mental effects of a single oral dose of ephedrine (ephedrine HCl 30 or 40 mg), fenfluramine (fenfluramine HCl 15 or 20 mg), phentermine (7.5 or 11.25 mg) and prolintane (prolintane HCl 10 or 20 mg) were compared in a double-blind placebo-controlled study. Each group consisted of 16-43 healthy volunteer medical students. The subjects fasted for at least 3 hr before drug administration and further until the end of the experiment. All the parameters were measured just prior to giving the drug, and 1.5 hr and 2.5 hr afterwards. Ephedrine significantly increased systolic blood pressure (p less than 0.05) and heart rate (p less than 0.01), whereas the other sympathomimetics affected these parameters only slightly or negligibly. None of the drugs markedly changed the tapping rate of the dominant hand. Mental activity was evaluated with a self-rating check list consisting of various mental modalities. None of the sympathomimetics significantly modified the mental activity. Memory, learning and concentration ability were evaluated with sign recording and digit span tests. In the digit span test no changes were obtained. In the sign recording test (for 3 min), phentermine increased significantly the recording score at both 1.5 hr (p less than 0.05) and 2.5 hr (p less than 0.005), and prolintane at 2.5 hr (p less than 0.05) after drug administration. The results suggest that in the doses given, which are commonly used in medical practice, ephedrine has the most pronounced cardiovascular effects, while phentermine and prolintane seem to be most active in the performance of some mental tasks.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6471970&dopt=Abstract
kwd match ionamin online literature
Dream Pharmaceuticals Rx Online Lipitor
Dream Pharmaceuticals Rx Online Paxil
Dream Pharmaceuticals Rx Online Phentermine
DreamPharm: Herbal and Nutritional supplements online ||
Hair Million herbal formula for hair loss and hair growth ||
Dream Pharmaceuticals Rx: Prescription Drugs Online || Tramadol Online || Paxil Online || Buspar Online || Cialis Online || Antibiotics Online
Antibiotics and prescription medications online literature ||
E-Mail Us