Ionamin online research references
J Reticuloendothel Soc. 1983 Apr;33(4):293-303.
Particle binding, phagocytosis, and plastic substrate adherence characteristics of alveolar macrophages from rats acutely treated with chlorphentermine.
Lehnert BE, Ferin J.
The effects of acute treatment with the phospholipidosis-inducing agent chlorphentermine (CP) on alveolar macrophage (AM) function heretofore have not been investigated. We evaluated the effects of acute CP treatment on the functional status of AM by comparing Fc receptor (FcR) and "nonspecific substance receptor"-mediated particle binding and phagocytic activities, as well as the plastic substrate adherence characteristics of AM lavaged from control (CONT-AM) and CP-treated (CP-AM) rats. Acute CP treatment caused an impairment in AM phagocytosis and binding of sheep red blood cells opsonized with immunoglobulin G (IgG). Although CONT-AM and CP-AM avidities for tanned human red blood cells were indistinguishable, phagocytosis of these particles by CP-AM was diminished in a manner similar to that found for FcR-mediated phagocytosis. Analyses of the distributions of test particles in phagocytizing CONT-AM and CP-AM indicated that the phagocytic activity of a subset of CP-AM was compromised by drug treatment. Populations of CP-AM were also found to be less adherent in a plastic substrate adherence assay verified with a poorly adherent AM population. Unlike studies involving chronic CP-treatment, our studies indicate acute CP administration results in an impairment in AM phagocytic activity and a reduction in FcR-mediated particle binding.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6834364&dopt=Abstract
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Acta Otolaryngol. 1983 Mar-Apr;95(3-4):307-13.
Experimental lipidosis of the inner ear. Morphological and functional results.
Bichler E, Wieser M.
Chronic administration of chlorphentermine in young rats induces an accumulation of lysosomes containing phospholipids in the inner ear. The inner hair cells, the dark cells of the stria vascularis, the perikarya of the spiral ganglion and some supporting cells are those most affected, whereas the outer hair cells always remain free. Most of the nerve fibres coursing radially to the inner hair cells as well as some tunnel crossing and outer spiral fibres are swollen, filled with osmiophilic material and vacuoles and sometimes degenerated. After discontinuing the treatment the changes remain, though to a lesser degree. The inclusions lead to changes in the cochlear compound action potential. The threshold, the latency of the first component and the time difference of the individual components are clearly changed at higher sound levels. After stopping chlorphentermine feeding the hearing ability improves but it does not become normal. Since the inclusions are found mainly in the inner hair cells and nerve fibres, we assume that the lipid turnover in these structures is especially high.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6837284&dopt=Abstract
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Exp Mol Pathol. 1983 Jun;38(3):310-21.
Chlorphentermine-induced neonatal and maternal pulmonary phospholipidosis in rats.
Thoma-Laurie DL, Walker ER, Reasor MJ.
Pregnant rats were treated on Days 16-20 of pregnancy with 30 mg/kg chlorphentermine hydrochloride (CP) or an equal volume of 0.9% NaCl. Females delivered on Day 21 and neonates were examined 12 hr postpartum. Electron micrographs showed the CP neonates to have lamellar inclusions, characteristic of drug-induced phospholipidosis in Type I and Type II cells, macrophages, and nonciliated bronchiolar epithelial cells of the lung. These inclusions were either unicentric, multicentric, or consisted of whorls of membranous material. The content of total phospholipids was increased in neonatal lung as a result of CP treatment. A decrease in the percentage of total phospholipid present as phosphatidylinositol plus phosphatidylserine and an increase in the content of disaturated phosphatidylcholine were found in neonatal lung as a result of maternal chlorphentermine treatment. In maternal lung, increases were seen in the content of total phospholipids, total phosphatidylcholine, disaturated phosphatidylcholine, and phosphatidylinositol plus phosphatidylserine. A decrease in the percentage of sphingomyelin was also found. The results of this study indicate that following prepartum maternal administration of CP morphological changes are accompanied by biochemical alterations which are consistent with the induction of phospholipidosis as observed in neonatal lung. These biochemical changes were different than those associated with the induction of this disorder in the maternal lung.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6852205&dopt=Abstract
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