Ionamin online research references
Eur J Drug Metab Pharmacokinet. 1981;6(2):127-33.
A compartmental model for the uptake of chlorphentermine in isolated perfused rat lung.
Minchin RF, Ilett KF, Madsen BW.
Equilibrium binding studies in vitro have established that chlorphentermine (CP) can be accumulated in rat lung by both binding and partitioning. Kinetic analysis of CP uptake in the isolated organ assuming an exponential process also suggests two separate mechanisms, one being saturable binding or transport, and the other, non-saturable partitioning. The present study was concerned with an alternative compartmental representation of the uptake process, and the validity of conclusions based on an exponential model. A three compartment model was finally selected which explain ed the observed uptake over a wide range of CP perfusate concentrations (2.5 x 10(-7) - 2.5 x 10(-5) mol/L) to within experimental error; it consisted of a binding and partitioning compartment in addition to one associated with the vascular bed. At low perfusate concentrations (2.5 x 10(-7) mol/L) uptake was essentially due to binding, while at higher perfusate concentrations (2.5 x 10(-5) mol/L) most uptake was due to partitioning. The total number of kinetically estimated binding sites (0.109 mumol/g) was less than that found by equilibrium dialysis for lung homogenates in vitro (8.3 mumol/g), suggesting an accessibility limitation for binding sites in the isolated preparation receiving a brief (10 min) perfusion. The data also indicate that there are probably two classes of binding sites or regional concentration of CP in the lung. It is proposed that interpretation of exponential model parameters may be problematical.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7274307&dopt=Abstract
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Am J Clin Nutr. 1981 Dec;34(12):2763-9.
The contribution of increased thermogenesis to the effect of anorectic drugs on body composition in mice.
Arch JR.
The study investigated whether changes in body composition of normal and genetically obese C57BL/6J (ob/ob) mice caused by the anorectic drugs phentermine, diethylpropion, fenfluramine, and mazindol are entirely due to reduced food intake. Mice were dosed daily (25 mg/kg po) for 28 days after which time carcass composition was determined. Compared to controls fed at libitum, reductions in food intake were for phentermine, 7%; fenfluramine, 17%; diethylpropion, 17%, whereas reduction in body lipid content were for phentermine, 16%; mazindol, 18%; fenfluramine, 8%; diethylpropion, 10%. Since diet restriction by 22% (in the absence of treatment with any drug) resulted in a body lipid content 12% below that of controls fed ad libitum, these results suggest that some of the lipid loss caused by phentermine and possibly mazindol is due to increased energy expenditure. In support of this conclusion, phentermine and mazindol increased energy expenditure in normal mice by 35% compared to untreated controls in the 6 h after dosing but diethylpropion and fenfluramine had little or no effect. Determination of the carcass composition of the normal mice confirmed that phentermine has a metabolic antiobesity effect. Fenfluramine had an unexpected effect on carcass composition in normal mice.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7315777&dopt=Abstract
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Am J Hosp Pharm. 1981 Dec;38(12):1922-4.
Compatibility of mephentermine sulfate with hydrocortisone sodium succinate or aminophylline in 5% dextrose injection.
Jhunjhunwala VP, Bhalla HL.
The compatibility and stability of mephentermine sulfate with hydrocortisone sodium succinate or aminophylline in 5% dextrose injection were studied. Mephentermine sulfate injection (equivalent to mephentermine 300 mg) was added to both hydrocortisone sodium succinate injection (equivalent to hydrocortisone 100 mg--admixture I) and aminophylline injection 250 mg (admixture II), each in 5% dextrose injection 400 ml. The solutions were stored in sealed USP type I containers and stored at 0-4 degrees C, 30 +/- 2 degrees C, and 45 +/- 1 degree C. Aliquots were drawn initially and at 4 and 24 hours for pH, drug content, and degradation product determinations. Mephentermine sulfate content was analyzed by a spectrophotometric method involving ion-pair extraction with tropaeolin 00. Hydrocortisone sodium succinate and aminophylline were analyzed by color reaction with isoniazid and UV spectrophotometry, respectively. The content of mephentermine and total hydrocortisone showed no change in admixture I under all test conditions. Hydrocortisone sodium succinate ester hydrolyzed slowly, but not more than 5% after 24 hours at 45 degrees C. There was no appreciable loss of mephentermine sulfate or aminophylline potency in admixture II. The pH of the solutions did not change over the period of study. The results indicate that both admixtures were compatible and stable under the tested storage conditions for at least 24 hours.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7325174&dopt=Abstract
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