Ionamin online research references
Int J Obes Relat Metab Disord. 1998 Apr;22(4):325-8.
Effects of phentermine on striatal dopamine and serotonin release in conscious rats: in vivo microdialysis study.
Balcioglu A, Wurtman RJ.
Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Cambridge 02139, USA.
OBJECTIVE: To measure the effects of phentermine, an appetite supressant, on the release of brain dopamine (DA) and serotonin (5-HT) into striatal dialysates of freely moving rats. DESIGN: Microdialysis and high performance liquid chromatography. SUBJECTS: Unanesthetized rats. MEASUREMENTS: Samples collected every 20 min were assayed for both neurotransmitters in a single run, using high performance liquid chromatography with electrochemical detection. RESULTS: Baseline levels of DA and 5-HT in dialysates were 56+/-16 and 3+/-0.6 fmol/20 microl, respectively. Administration of phentermine (2 or 5 mg/kg) increased dialysate DA concentrations to 147+/-17% (P < 0.01) and 320+/-89% (P < 0.01) of baseline, respectively, without significantly affecting 5-HT concentrations. Pretreatment with tetrodotoxin (TTX, 60 min, 1 microM), which abolished the basal release of DA and 5-HT into striatal dialysates, diminished the increase in DA concentrations induced by phentermine, but did not completely block it. Phentermine (2 or 5 mg/kg, i.p.) still stimulated DA release to 27+/-13% and 85+/-15% of baseline, respectively, in the presence of TTX. CONCLUSION: Phentermine increases brain DA but not 5-HT release in freely moving rats, and TTX reduces, but does not fully block this effect. This pattern is similar to that known to be produced by d-amphetamine.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9578237&dopt=Abstract
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Acta Crystallogr C. 1998 Apr 15;54 ( Pt 4):497-9.
Mephentermine hemisulfate monohydrate: an adrenergic agent.
Sengupta R, Banerjee R, Dattagupta JK.
Crystallography & Molecular Biology Division, Saha Institute of Nuclear Physics, Calcutta, India.
The title molecule, a hydrated hemisulfate salt of ethyl(2-methyl-1-phenyl-2-propyl)ammonium, C11H18N+.0.5SO4(2-).H2O, consists of a phenethylamine skeleton in which the N atom is protonated. There are two molecules in the asymmetric unit, with the S atom of the SO4(2-) ion lying on a pseudo-twofold axis. The ethylamine side chain is in an extended conformation in both the symmetry-independent molecules. The distance of the N atom from the centre of the benzene ring is 5.1 A for molecule 1 and 5.3 A for molecule 2. The packing is stabilized by N-H...O and O-H...O hydrogen bonds.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9604308&dopt=Abstract
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J Med Primatol. 1977;6(6):367-75.
Comparative metabolism of the amphetamine drugs of dependence in man and monkeys.
Caldwell J, Dring LG, Franklin RB, Koster U, Smith RL, Williams RT.
The use of animal models to study drug dependence and tolerance requires that the species used metabolizes the drugs like man, a condition frequently not fulfilled by non-primate species. The metabolic fate of several amphetamine drugs, namely amphetamine, norephedrine, chlorphentermine and phenmetrazine, in the rhesus monkey and the tamarin and two non-primate species has been investigated and compared to that found for man. The findings show that the two primate species metabolize these drugs in a manner similar to that in man.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=96262&dopt=Abstract
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