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J Antimicrob Chemother. 2000 Oct;46(4):621-4.
Antimicrobial resistance in Streptococcus pyogenes isolates in Berlin.
Arvand M, Hoeck M, Hahn H, Wagner J.
Institut fur Infektionsmedizin, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany. arvanedat.fu-berlin.de
A total of 212 clinical Streptococcus pyogenes isolates were tested for susceptibility to various antibiotics by agar dilution. The overall frequency of erythromycin resistance was 12.7%, being higher in isolates from children (18.9%) than in those from adult patients (10.7%). Similar results were found for clarithromycin, while 2.8% of the isolates were resistant to ciprofloxacin. All strains were susceptible to penicillin and cefotaxime. Of the erythromycin-resistant isolates subjected to the double-disc diffusion test for erythromycin and clindamycin, 35% expressed constitutive and 55% inducible resistance to clindamycin. Ten per cent were susceptible to clindamycin (M-phenotype). Thus, a high rate of macrolide resistance in S. pyogenes has emerged in Berlin.
online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11020262&dopt=Abstract
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