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J Antimicrob Chemother. 2003 Feb;51(2):443-6.
Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials.

Pankuch GA, Jacobs MR, Appelbaum PC.

Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.

A spectrum of pneumococci with varying susceptibilities to beta-lactams, macrolides and quinolones was tested for susceptibility to nine antibiotics, including the novel lipopeptide daptomycin. Daptomycin was active against all strains (MIC range </=0.5 mg/L; MIC(50) 0.125 mg/L; MIC(90) 0.25 mg/L). All pneumococci were susceptible to vancomycin, teicoplanin, linezolid and quinupristin/dalfopristin, with MICs < 4.0 mg/L. Time-kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12562720&dopt=Abstract







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