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  • Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.
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  • Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells.
  • A novel approach using transcomplementing adenoviral vectors for gene therapy of adrenocortical cancer.
  • The Construction and Expression of Polycistronic Retroviral Vector Carrying Genes of TNF-alpha, IL-2 and NeoR.
  • Tumor growth suppression by a retroviral vector displaying scFv antibody to CEA and carrying the iNOS gene.
  • Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques.
  • Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites.
  • Use of a non-depleting anti-CD4 antibody to modulate the immune response to coagulation factors VIII and IX.
  • The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer.
  • Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels.
  • Engraftment of post 5-fluorouracil murine marrow into minimally myeloablated (100 cGy) murine hosts.
  • Gene therapy for meningioma: improved gene delivery with targeted adenoviruses.
  • Adenovirus mediated gelsolin gene therapy for orthotopic human bladder cancer in nude mice.
  • Sustained hepatic and renal glucose-6-phosphatase expression corrects glycogen storage disease type Ia in mice.
  • Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep.
  • Both u-PA inhibition and vitronectin binding by plasminogen activator inhibitor 1 regulate HT1080 fibrosarcoma cell metastasis.
  • Nonhereditary enhancement of progeny growth.
  • Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels.
  • Muscle-based gene therapy and tissue engineering for treatment of growth plate injuries.
  • Insertion of an exogenous domain in the adenovirus type 2 fiber globular region.
  • Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice.
  • In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice.
  • CD2 is a dominant target for allogeneic responses.
  • Adenovirus gene transfer vector toxicity to mouse embryos: implications for human IVF.
  • Comparison of the TCR zeta-chain with the FcR gamma-chain in chimeric TCR constructs for T cell activation and apoptosis.
  • The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells.
  • Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergy.
  • Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinemia in rats.
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  • Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease.
  • Assessment of oropharyngeal cancer.
  • A cancer gene therapy approach through translational control of a suicide gene.
  • T cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients.
  • Expression of recombinant adeno-associated virus in the brain of rats with a focal embolic stroke via carotid artery.
  • Replication competent helper functions for recombinant AAV vector generation.
  • Gene transfer of soluble TGF-beta type II receptor inhibits experimental proliferative vitreoretinopathy.
  • Validation in mesenchymal progenitor cells of a mutation-independent ex vivo approach to gene therapy for osteogenesis imperfecta.
  • Elevated blood pressure is not related to saliva flow in patients with Sjogren's syndrome.
  • Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma.
  • Progress and challenges in viral vector-mediated gene transfer to the brain.
  • Retroviral recombination: review of genetic analyses.
  • Human foamy virus integrase fails to catalyse the integration of a circular DNA molecule containing an LTR junction sequence.
  • Identification of FGF receptor-binding peptides for cancer gene therapy.
  • Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models.
  • A tandemly repeated thyroglobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas.
  • The woodchuck interferon-alpha system: Cloning, family description, and biologic activity.
  • Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy.
  • A microinjected COL7A1-PAC vector restores synthesis of intact procollagen VII in a dystrophic epidermolysis bullosa keratinocyte cell line.
  • Improved foamy virus vectors with minimal viral sequences.
  • Sustained release of low-dose ganciclovir from a silicone formulation prolonged the survival of rats with gliosarcomas under herpes simplex virus thymidine kinase suicide gene therapy.
  • Novel prostate-specific promoter derived from PSA and PSMA enhancers.
  • Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs.
  • Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy.
  • On the scientific and ethical issues of fetal somatic gene therapy.
  • Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome.
  • Confocal laser microscopy of chondrocytes that received gene transfer using in vitro electroporation.
  • Targeted lysosome disruptive elements for improvement of parenchymal liver cell-specific gene delivery.
  • Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis.
  • In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique.
  • siRNA-mediated gene silencing in vitro and in vivo.
  • Marked enhancement of antitumor immune responses in mouse brain tumor models by genetically modified dendritic cells producing Semliki Forest virus-mediated interleukin-12.
  • Development and optimization of a real-time quantitative PCR-based method for the titration of AAV-2 vector stocks.
  • Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors.
  • Antiinflammatory effect of retrovirally transfected interleukin-10 on monosodium urate monohydrate crystal-induced acute inflammation in murine air pouches.
  • Application of SFHR to gene therapy of monogenic disorders.
  • A site-specific mutation of tyrosine hydroxylase reduces feedback inhibition by dopamine in genetically modified cells grafted in parkinsonian rats.
  • Expression of PiT1 and PiT2 retroviral receptors and transduction efficiency of tumor cells.
  • Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft.
  • Keratinocyte gene therapy: cytokine gene expression in local keratinocytes and in circulation by introducing cytokine genes into skin.
  • Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression.
  • Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloon-denuded rabbit aorta.
  • Lipid-mediated gene transfection of intercellular adhesion molecule-1 suppresses the peritoneal metastasis of gastric carcinoma.
  • Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4.
  • Role of Sp1 in insulin regulation of gene expression.
  • OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases.
  • Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin.
  • Absence of tight junction formation in an allogeneic graft cell line used for developing an engineered artificial salivary gland.
  • Preparation of human single chain Fv antibody against hepatitis C virus E2 protein and its identification in immunohistochemistry.
  • Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents.
  • Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats.
  • Targeting immune effector molecules to human tumor cells through genetic delivery of 5T4-specific scFv fusion proteins.
  • Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapy-based approach to the treatment of cancer.
  • Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2.
  • Intrasplenic transplantation of syngenic hepatocytes modified by IFN-gamma gene ameliorates hepatic fibrosis in rats.
  • Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs.
  • Human haematopoiesis in steady state and following intense perturbations.
  • Analysis of inhibitory action of modified U1 snRNAs on target gene expression: discrimination of two RNA targets differing by a 1 bp mismatch.
  • Functional improvement of dystrophic muscle by myostatin blockade.
  • Gene therapy of apolipoprotein E-deficient mice using a novel macrophage-specific retroviral vector.
  • Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis.
  • Autologous and MHC class I-negative allogeneic tumor cells secreting IL-12 together cure disseminated A20 lymphoma.
  • In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor.
  • Retroviral gene transfer to human epidermal keratinocytes correlates with integrin expression and is significantly enhanced on fibronectin.
  • PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver.
  • The murine-reduced folate carrier gene can act as a selectable marker and a suicide gene in hematopoietic cells in vivo.
  • Gene transfer to coronary artery bypass conduits.
  • Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
  • Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy.
  • Autosomal-dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary.
  • Size and topology of exogenous DNA as determinant factors of transgene transcription in mammalian cells.
  • Inhibition of growth of human prostate cancer xenograft by transfection of p53 gene: gene transfer by electroporation.
  • Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells.
  • Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies.
  • Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.
  • Development of a biosensor-based method for detection and isotyping of antibody responses to adenoviral-based gene therapy vectors.
  • Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer.
  • Lack of toxicity of EGFR antisense gene therapy.
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  • Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer.
  • rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid: a new option as immuno-therapy for osteosarcoma?
  • Optimisation of transfection conditions of CD34+ hematopoietic cells derived from human umbilical cord blood.
  • Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy.
  • Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model.
  • Hypotensive effect of encapsulated genetically engineered fibroblasts expressing mutant atrial natriuretic peptide in hypertensive rats
  • Reaction of keratinocytes to exogenous DNA.
  • A new scalable method for the purification of recombinant adenovirus vectors.
  • Phosphorotioated oligonucleotides trigger synthesis of human coagulation serine proteases.
  • Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies.
  • Thermoradiotherapy combined with p53 gene therapy of human salivary gland adenocarcinoma cell line.
  • Encapsulation of packaging cell line results in successful retroviral-mediated transfer of a suicide gene in vivo in an experimental model of glioblastoma.
  • Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models.
  • Novel targets and therapeutic strategies for type 2 diabetes.
  • Prediction of protein signal sequences.
  • Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity.
  • Repopulation of rat liver by fetal hepatoblasts and adult hepatocytes transduced ex vivo with lentiviral vectors.
  • Myths concerning the use of cationic liposomes in vivo.
  • Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11.
  • Efficient production of human FVIII in hemophilic mice using lentiviral vectors.
  • Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts.
  • Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing.
  • Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy.
  • Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11).
  • Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors.
  • In Vivo Noninvasive Imaging for Gene Therapy.
  • Targeting of Synthetic Gene Delivery Systems.
  • Oxidative stress and heart disease: cardiac dysfunction, nutrition, and gene therapy.
  • Hearing and hair cells are protected by adenoviral gene therapy with TGF-beta1 and GDNF.
  • Engineering nuclear localization signals in modular protein vehicles for gene therapy.
  • Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice.
  • Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.
  • Gene therapy of streptozotocin-induced diabetes by intramuscular delivery of modified preproinsulin genes.
  • PCR-based detection of a rare linear DNA in cell culture.
  • Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication.
  • Marfan syndrome, magnesium status and medical prevention of cardiovascular complications by hemodynamic treatments and antisense gene therapy.
  • Characterisation of functional biotinylated TNF-alpha targeted to the membrane of apoptotic melanoma cells.
  • Functional analysis of peritoneal lymphoid tissues by GFP expression in mice--possible application for targeting gene therapy against peritoneal dissemination
  • The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow.
  • Hereditary inclusion body myopathy: The Middle Eastern genetic cluster.
  • Telomerase as a promising target for human cancer gene therapy.
  • Evaluation of Optimal Expression Cassette in Retrovirus Vector for beta-Thalassemia Gene Therapy.
  • Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity.
  • Identification of the human IAI.3B promoter element and its use in the construction of a replication-selective adenovirus for ovarian cancer therapy.
  • Artificial cells for replacement of metabolic organ functions.
  • Interleukin-2 gene therapy of chronic neuropathic pain.
  • Survivin mutants reverse the malignancy of HeLa cells
  • Muscle satellite cells.
  • Bio-safety testing for retroviral vector as gene therapy delivery system
  • Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria.
  • Radioprotective gene therapy.
  • The pyruvate dehydrogenase complex as a target for gene therapy.
  • PET-based molecular imaging in neuroscience.
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  • Complete sequence and genomic analysis of rhesus cytomegalovirus.
  • Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
  • Inhibition of human telomerase in MKN-45 cell line by antisense hTR expression vector induces cell apoptosis and growth arrest.
  • Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells.
  • Protective effect of adenoviral-mediated brain derived neurotrophic factor gene on spiral ganglion
  • Detection of mutant p53 in hepatocellular cancer from Turkey and its correlation with clinicopathologic parameters.
  • Titer determination of Ad5 in blood: a cautionary note.
  • Gene therapy for myocardial angiogenesis: with direct intramuscular gene transfer of naked deoxyribonucleic acid encoding vascular endothelial growth factor and cell transplantation of vascular endothelial growth factor transfected H9c2 myoblast.
  • The coxsackievirus and adenovirus receptor acts as a tumour suppressor in malignant glioma cells.
  • Triple helix: a new promise for gene therapy
  • The common mitochondrial DNA deletion deltamtDNA(4977): shedding new light to the concept of a tumor suppressor mutation.
  • Prospects for CD40-directed experimental therapy of human cancer.
  • The therapeutic potential of novel antiangiogenic therapies.
  • Maximal lentivirus-mediated gene transfer and sustained transgene expression in human hematopoietic primitive cells and their progeny.
  • Sex steroid hormones in primary Sjogren's syndrome.
  • A forward look at therapy for pediatric movement disorders.
  • Skeletal muscle as an artificial endocrine tissue.
  • Emerging significance of plasmid DNA nuclear import in gene therapy.
  • Replicative retroviral vectors for cancer gene therapy.
  • Inhibiting AIDS in the central nervous system: gene delivery to protect neurons from HIV.
  • Assembly of cholera toxin B subunit full-length rotavirus NSP4 fusion protein oligomers in transgenic potato.
  • Pre-clinical in vivo evaluation of pseudotyped adeno-associated virus (AAV) vectors for liver gene therapy.
  • The impact of molecular biology on the practice of pediatric critical care medicine.
  • Recombinant adenoviruses expressing dominant negative insulin-like growth factor-I receptor demonstrate antitumor effects on lung cancer.
  • Polybrene increases retrovirus gene transfer efficiency by enhancing receptor-independent virus adsorption on target cell membranes.
  • Intensification of Antitumor Effect by T Helper 1-dominant Adoptive Immunogene Therapy for Advanced Orthotopic Colon Cancer.
  • Identification of bone marrow stromal cells and expression of tyrosine hydroxylase gene in them
  • Effects of adenovirus-mediated SV5 fusogenic glycoprotein expression on tumor cells.
  • Improvement of exogenous DNA nuclear importation by nuclear localization signal-bearing vectors: a promising way for non-viral gene therapy?
  • Adenovirus-mediated gene therapy with an antiangiogenic fragment of thrombospondin-1 inhibits human leukemia xenograft growth in nude mice.
  • Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells.
  • Potentiated Gene Delivery to Tumors Using Herpes Simplex Virus/Epstein-Barr Virus/RV Tribrid Amplicon Vectors.
  • A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene.
  • Gene delivery into prostate cancer cells by holmium laser application.
  • RNA interference in functional genomics and medicine.
  • Age-associated reduction of nuclear protein import in human fibroblasts.
  • In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasia.
  • Adenovirus with insertion-mutated E1A selectively propagates in liver cancer cells and destroys tumors in vivo.
  • Development of gene therapy for hematopoietic stem cell using viral vectors
  • Uncovering the genetics of systemic lupus erythematosus: implications for therapy.
  • Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project.
  • The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells.
  • Suicide gene therapy using keratin 19 enhancer and promoter in malignant mesothelioma cells.
  • Chimeric DNA-RNA hammerhead ribozyme targeting PDGF A-chain mRNA specifically inhibits neointima formation in rat carotid artery after balloon injury.
  • Suppression of tumor formation and induction of natural killer cell activity in BALB/c nude mice by human B7-1 (CD80) gene transfer subcutaneously injected with human hepatocellular carcinoma cells (Huh-7)
  • Supercoiled plasmid DNA: selective purification by thiophilic/aromatic adsorption.
  • Long-term ex vivo expansion of human fetal liver primitive haematopoietic progenitor cells in stroma-free cultures.
  • Biodistribution study of phosphonolipids: a class of non-viral vectors efficient in mice lung-directed gene transfer.
  • Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells.
  • PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa.
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/{beta}2m -/- repopulating mobilized human peripheral blood CD34+ cells.
  • Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice.
  • Nanotechnology and medicine.
  • Approaches to utilize mesenchymal progenitor cells as cellular vehicles.
  • Simian immunodeficiency virus-based lentivirus vector for retinal gene transfer: a preclinical safety study in adult rats.
  • Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy.
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  • Mouse model for human arginase deficiency.
  • Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2.
  • Down-regulation of metastatic phenotype in human melanoma cells by controlled expression of anti-sense matrix metalloproteinase 9
  • Generation of a chimeric mouse reconstituted with green fluorescent protein-positive bone marrow cells: a useful model for studying the behavior of bone marrow cells in regeneration in vivo.
  • Transduction and selection of human T cells with novel CD34/thymidine kinase chimeric suicide genes for the treatment of graft-versus-host disease.
  • Expression of dystrophin driven by the 1.35-kb MCK promoter ameliorates muscular dystrophy in fast, but not in slow muscles of transgenic mdx mice.
  • In vitro selection of viral vectors with modified tropism: the adeno-associated virus display.
  • TGF-{beta} signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro.
  • Experimental study of thymidine kinase gene therapy of neuroblastoma in vitro and in vivo.
  • Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation
  • Induction of human T lymphocyte cytotoxicity and inhibition of tumor growth by tumor-specific diabody-based molecules secreted from gene-modified bystander cells.
  • Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
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  • Immunomodulation for treatment and prevention of atherosclerosis.
  • Immune monitoring of human gene therapy trials: potential application to leukemia and lymphoma.
  • Differentiation of rat bone marrow stromal cells into neuron induced by baicalin
  • Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice.
  • Intravenous delivery of adenovirus-mediated soluble FLT-1 results in liver toxicity.
  • Specific transgene expression in human and mouse CD4+ cells using lentiviral vectors with regulatory sequences from the CD4 gene.
  • Thymopoiesis and T cell development in common gamma chain-deficient dogs.
  • Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
  • Effect of liposomal transfection of cyclin A antisense oligodeoxynucleotide (ASON) on HL-60 cell proliferation and apoptosis
  • Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization.
  • Specific packaging of spliced retroviral vector transcripts lacking the Psi-region.
  • Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.
  • Lung cancer vaccines and gene therapy.
  • Myocardial expression of baculoviral p35 alleviates doxorubicin-induced cardiomyopathy in rats.
  • Comparative analysis of the effects of packaging signal, transgene orientation, promoters, polyadenylation signals, and E3 region on growth properties of first-generation adenoviruses.
  • Gene therapy vectors based on adeno-associated virus type 1.
  • The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues.
  • Molecular therapeutics of HBV.
  • The re-emergence of aerosol gene delivery: a viable approach to lung cancer therapy.
  • Hemophilia: treatment options in the twenty-first century.
  • Adenovirus-mediated overexpression of a cyclin-dependent kinase inhibitor, p57Kip2, suppressed vascular smooth muscle cell proliferation.
  • Vesicular monoamine transporter-2 and aromatic L-amino acid decarboxylase enhance dopamine delivery after L-3, 4-dihydroxyphenylalanine administration in Parkinsonian rats.
  • Electroporation-mediated and EBV LMP1-regulated gene therapy in a syngenic mouse tumor model.
  • CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines.
  • Notch1 and Numb genes are inversely expressed as oligodendrocytes differentiate.
  • Adenoviral transfection of hepatocytes with the thioredoxin gene confers protection against apoptosis and necrosis.
  • Gene therapy: Future strategies and therapies.
  • Semliki Forest virus vectors for gene therapy.
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  • Effects of antisense peptide nucleic acid to platelet-derived growth factor A-chain on growth of vascular smooth muscle cells.
  • Immunogenicity of herpes simplex virus type 1 mutants containing deletions in one or more alpha-genes: ICP4, ICP27, ICP22, and ICP0.
  • Arachidonate CYP hydroxylases of kidney contribute to formation of hypertension and maintenance of blood pressure.
  • HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
  • Adenovirus-mediated interleukin-2 gene therapy of nociception.
  • Construction of an EGF receptor-mediated histone H1(0)-based gene delivery system.
  • Improved packaging system for generation of high-level noncytotoxic HSV-1 amplicon vectors using Cre-loxP site-specific recombination to delete the packaging signals of defective helper genomes.
  • Photochemical internalization (PCI)--a novel technology for release of macromolecules from endocytic vesicles.
  • Induction of cre recombinase activity using modified androgen receptor ligand binding domains: a sensitive assay for ligand-receptor interactions.
  • Effect of human hepatocyte growth factor on promoting wound healing and preventing scar formation by adenovirus-mediated gene transfer.
  • Potential of gene therapy for pediatric neurotransmitter diseases: lessons from Parkinson's disease.
  • Melanoma cells can tolerate high levels of transcriptionally active endogenous p53 but are sensitive to retrovirus-transduced p53.
  • Combined radiation and cytochrome CYP4B1/4-ipomeanol gene therapy using the EGR1 promoter.
  • Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors.
  • Constrution of eucaryotic expression plasmid carrying the BMP7 gene and expression in mesenchymal stem cells
  • Inhibition effects of c-erbB-2 and c-raf-1 antisense oligodeoxynucleotides combined transfection on the human ovarian carcinoma transplanted subcutaneously in nude mice
  • Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors.
  • Gene therapy for HIV/AIDS: the potential for a new therapeutic regimen.
  • Intracellular expression of multimerized antisense TAR-Core RNAs inhibit the replication of human immunodeficiency virus type 1 in human CD4+ T lymphocytes.
  • Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter.
  • Effect of a DNA nuclear targeting sequence on gene transfer and expression of plasmids in the intact vasculature.
  • Recombinant AAV serotype 1 transduction efficiency and tropism in the murine brain.
  • Gene therapy for the hemoglobin disorders.
  • Screening for mutations in a novel retinal-specific gene among Chinese patients with retinitis pigmentosa.
  • Human embryonic-derived hematopoietic repopulating cells require distinct factors to sustain in vivo repopulating function.
  • Construction of an allosteric trans-maxizyme targeting for two distinct oncogenes.
  • In vivo manipulation of interleukin-2 expression by a retroviral tetracycline (tet)-regulated system.
  • Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord.
  • Gene therapy of rat prolactinomas mediated by adenoviral vectors with rat tyrosine hydroxylase gene
  • The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
  • Identification of an HLA-A*0201-restricted epitopic peptide from human dystrophin: application in duchenne muscular dystrophy gene therapy.
  • Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations.
  • E1A, E1B double-restricted adenovirus for oncolytic gene therapy of gallbladder cancer.
  • A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer.
  • Size-exclusion chromatography purification of high-titer vesicular stomatitis virus G glycoprotein-pseudotyped retrovectors for cell and gene therapy applications.
  • E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells.
  • Cell cycle dependence of retroviral transduction: An issue of overlapping time scales.
  • Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer.
  • Embolization of portal vein branches induces hepatocyte replication in swine: a potential step in hepatic gene therapy.
  • Reversal of hypopigmentation in phenylketonuria mice by adenovirus-mediated gene transfer.
  • CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge.
  • Mitosis enhances transgene expression of plasmid delivered by cationic liposomes.
  • Inner ear transgene expression after adenoviral vector inoculation in the endolymphatic sac.
  • Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study.
  • Adenovirus-mediated expression of Fas ligand induces apoptosis of human prostate cancer cells.
  • Retroviral transduction and expansion of peripheral blood lymphocytes for the treatment of mucopolysaccharidosis type II, Hunter's syndrome.
  • Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells.
  • Expression of major histocompatibility complex antigens in squamous cell carcinomas of the head and neck: effects of interferon gene transfer.
  • Site-specific fluorescence labelling of recombinant polyomavirus-like particles.
  • Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors.
  • Ethanol improves adenovirus-mediated gene transfer and expression to the bladder epithelium of rodents.
  • Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.
  • Efficient transduction of human lymphocytes and CD34+ cells via human immunodeficiency virus-based gene transfer vectors.
  • Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors.
  • Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
  • Reverse transcription-competitive multiplex PCR improves quantification of mRNA in clinical samples--application to the low abundance CFTR mRNA.
  • In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression.
  • Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors.
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  • Cellular immunity delimits adenoviral gene therapy strategies for the treatment of neoplastic diseases.
  • Generation of retroviral vector for clinical studies using transient transfection.
  • Modulation of autoimmune disease in the MRL-lpr/lpr mouse by IL-2 and TGF-beta1 gene therapy using attenuated Salmonella typhimurium as gene carrier.
  • Overcoming the immune response to permit ex vivo gene therapy for spine fusion with human type 5 adenoviral delivery of the LIM mineralization protein-1 cDNA.
  • Evaluation of fibroblast-mediated gene therapy in a feline model of mucopolysaccharidosis type VI.
  • Macaque lymphocytes transduced by a constitutively expressed interferon beta gene display an enhanced resistance to SIVmac251 infection.
  • Inducible long-term gene expression in brain with adeno-associated virus gene transfer.
  • A strategy for enhancing the transcriptional activity of weak cell type-specific promoters.
  • Gene chemistry: functionally and conformationally intact fluorescent plasmid DNA.
  • E2F-1 regulates nuclear factor-kappaB activity and cell adhesion: potential antiinflammatory activity of the transcription factor E2F-1.
  • Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats.
  • Rewriting the "points to consider": the ethical impact of guidance document language.
  • Oxidation of alpha1-proteinase inhibitor by the myeloperoxidase-hydrogen peroxidase system promotes binding to immunoglobulin A.
  • Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.
  • Evaluation of an adenoviral vector encoding full-length human factor VIII in hemophiliac mice.
  • Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
  • BAPS Prize--1997. Fetal gene therapy: efficacy, toxicity, and immunologic effects of early gestation recombinant adenovirus. British Association of Paediatric Surgeons.
  • The effects of transferring tumor suppressor gene p16INK4A to p16INK4A-deleted cancer cells.
  • Neurofibromatosis type 2: genetic and clinical features.
  • Amplified Muc1-specific gene expression in colon cancer cells utilizing a binary system in adenoviral vectors.
  • Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.
  • Transgenic expression of CD40 ligand produces an in vivo antitumor immune response against both CD40(+) and CD40(-) plasmacytoma cells.
  • Design, characterization and testing of tRNA3Lys-based hammerhead ribozymes.
  • Systemic and central nervous system correction of lysosomal storage in mucopolysaccharidosis type VII mice.
  • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta.
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  • Gene therapy: adenovirus-mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo.
  • The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.
  • Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction.
  • Conditional expression of a dominant-negative c-Myb in vascular smooth muscle cells inhibits arterial remodeling after injury.
  • Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling.
  • Gene transfer into fetal baboon hematopoietic progenitor cells.
  • Induction of acute phase response genes in keratinocytes following exposure to oligodeoxynucleotides.
  • Efficient discrimination between different densities of target antigen by tetracycline-regulatable T bodies.
  • Inhibition of endothelial cell migration by gene transfer of tissue inhibitor of metalloproteinases-1.
  • Regulation of N-acetylgalactosamine 4-sulfatase expression in retrovirus-transduced feline mucopolysaccharidosis type VI muscle cells.
  • Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette.
  • Identification of the block in targeted retroviral-mediated gene transfer.
  • Plasma and CSF pharmacokinetics of ganciclovir in nonhuman primates.
  • Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.
  • High-titer, wild-type free recombinant adeno-associated virus vector production using intron-containing helper plasmids.
  • Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates.
  • Multidrug Resistance and Prodrug Activation for Cancer Gene Therapy of Breast Cancer.
  • In vivo electrotransfer of the cardiotrophin-1 gene into skeletal muscle slows down progression of motor neuron degeneration in pmn mice.
  • Enhanced short-term plasmid transfection of filtration surgery tissues.
  • Potential of ribozymes against deoxycytidine kinase to confer drug resistance to cytosine nucleoside analogs.
  • Self-selection by genetically modified committed lymphocyte precursors reverses the phenotype of JAK3-deficient mice without myeloablation.
  • Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies.
  • Novel chimeric p16 and p27 molecules with increased antiproliferative activity for vascular disease gene therapy.
  • New strategies in the treatment of restenosis
  • Autologous T lymphocytes may specifically recognize leukaemic B cells in patients with chronic lymphocytic leukaemia.
  • Localized expression of small RNA inhibitors in human cells.
  • Gene transfer of low levels of beta-glucuronidase corrects hepatic lysosomal storage in a large animal model of mucopolysaccharidosis VII.
  • DNA/dendrimer complexes mediate gene transfer into murine cardiac transplants ex vivo.
  • Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion.
  • Gene transfer into the fetal primate: evidence for the secretion of transgene product.
  • Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12.
  • Recombinant adenovirus vectors with knobless fibers for targeted gene transfer.
  • Conditionally immortalized mouse hepatocytes for use in liver gene therapy.
  • The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy.
  • Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs.
  • Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy.
  • IFN-gamma gene therapy by intrasplenic hepatocyte transplantation: a novel strategy for reversing hepatic fibrosis in Schistosoma japonicum-infected mice.
  • Transfer of the alpha 5(IV) collagen chain gene to smooth muscle restores in vivo expression of the alpha 6(IV) collagen chain in a canine model of Alport syndrome.
  • Novel approaches to treatment of sickle cell anaemia.
  • IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.
  • Continuous monitoring of the stimulated area in multifocal ERG.
  • The localization and functional contribution of striatal aromatic L-amino acid decarboxylase to L-3,4-dihydroxyphenylalanine decarboxylation in rodent parkinsonian models.
  • IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis.
  • CD31 (PECAM-1)-bright cells derived from AC133-positive cells in human peripheral blood as endothelial-precursor cells.
  • Dynamic restoration of dystrophin to dystrophin-deficient myotubes.
  • Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice.
  • CD34 expression on long-term repopulating hematopoietic stem cells changes during developmental stages.
  • Growth suppression of human coronary vascular smooth muscle cells by gene transfer of the transcription factor E2F-1.
  • Monitoring DNA/poly-L-lysine polyplex formation with time-resolved multiangle laser light scattering.
  • A gene therapy approach for treating T-cell-mediated autoimmune diseases.
  • Cytotoxic T-cell induction in metastatic melanoma patients undergoing recombinant vaccinia virus-based immuno-gene therapy.
  • The WI-1 adhesin blocks phagocyte TNF-alpha production, imparting pathogenicity on Blastomyces dermatitidis.
  • Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction.
  • Preclinical protocol for in vivo selection of hematopoietic stem cells corrected by gene therapy in Fanconi anemia group C.
  • Herpesvirus-mediated systemic delivery of nerve growth factor.
  • p53 Status and gene transfer experiments using CMV enhancer/promoter.
  • Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with alpha-fetoprotein promoter and Cre/lox P system.
  • Biosafety: future priorities for research in health care.
  • Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage.
  • Retroviral marking of human bone marrow fibroblasts: in vitro expansion and localization in calvarial sites after subcutaneous transplantation in vivo.
  • Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides.
  • Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase.
  • Purification of essentially RNA free plasmid DNA using a modified Escherichia coli host strain expressing ribonuclease A.
  • Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.
  • Evaluation of gene transfer efficiency by viral vectors to murine bladder epithelium.
  • Radioisotopic imaging allows optimization of adenovirus lung deposition for cystic fibrosis gene therapy.
  • Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells.
  • A novel approach for herpes simplex virus type 1 amplicon vector production, using the Cre-loxP recombination system to remove helper virus.
  • Muscle-specific promoters may be necessary for adeno-associated virus-mediated gene transfer in the treatment of muscular dystrophies.
  • Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors.
  • Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium.
  • Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA.
  • Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells.
  • The future of oncohematology
  • The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS.
  • In situ expression of soluble B7-1 in the context of oncolytic herpes simplex virus induces potent antitumor immunity.
  • Genetic analysis of two patients with adenosine deaminase (ADA)-deficiency: detection of three novel mutations and characterization of two paradoxical carriers
  • Differential influence of the E4 adenoviral genes on viral and cellular promoters.
  • Serum as a modulator of lipoplex-mediated gene transfection: dependence of amphiphile, cell type and complex stability.
  • Bcl-2 expression in higher-grade human glioma: a clinical and experimental study.
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  • Preclinical studies of a new generation retroviral vector for ovarian cancer BRCA1 gene therapy.
  • Prostate cancer radiosensitization in vivo with adenovirus-mediated p53 gene therapy.
  • Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer.
  • Selection of human antitumor single-chain Fv antibodies from the B-cell repertoire of patients immunized against autologous neuroblastoma.
  • A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo.
  • Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice.
  • Soluble donor MHC class I gene transfer to thymus promotes allograft survival in a high-responder heart transplant model.
  • Ventricular dysfunction clinical research in infants, children and adolescents.
  • Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo.
  • HSV vector cytotoxicity is inversely correlated with effective TK/GCV suicide gene therapy of rat gliosarcoma.
  • Sjogren's syndrome: a possible pathogenetic mechanism involving somatostatin.
  • abst 498
  • Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
  • Tissue-specific transcriptional targeting of a replication-competent retroviral vector.
  • Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis.
  • The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy.
  • Characteristics and biodistribution of cationic liposomes and their DNA complexes.
  • Inhibition of experimental lung metastasis by aerosol delivery of PEI-p53 complexes.
  • Targeting transgene expression to airway epithelia and submucosal glands, prominent sites of human CFTR expression.
  • A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors.
  • Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.
  • Metastatic and nonmetastatic models of retinoblastoma.
  • Combination gene therapy using multiple immunomodulatory genes transferred by a defective infectious single-cycle herpes virus in squamous cell cancer.
  • Cytoplasmic molecular delivery with shock waves: importance of impulse.
  • Hammerhead ribozymes selectively suppress mutant type I collagen mRNA in osteogenesis imperfecta fibroblasts.
  • Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.
  • Gene transfer to intact mesenteric arteries by electroporation.
  • Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.
  • Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors.
  • Bacterial DNA methylation and gene transfer efficiency.
  • MHC (major histocompatibility complex)-DRB genes and polymorphisms in common marmoset.
  • Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections.
  • Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanism.
  • Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders.
  • Blood clearance rates of adenovirus type 5 in mice.
  • Vascular endothelial growth gene therapy for narrowing of rabbit iliac artery
  • Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer.
  • Mesenchymal stem cells and gene therapy.
  • Nonviral in vivo gene therapy for tissue engineering of articular cartilage and tendon repair.
  • Gene therapy for osteoarthritis: new perspectives for the twenty-first century.
  • Development of multigene and regulated lentivirus vectors.
  • Transplant immunosuppression increases and prolongs transgene expression following adenoviral-mediated transfection of rat lungs.
  • Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.
  • Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells.
  • Induction of B-cell tolerance by retroviral gene therapy.
  • Adenovirus 5 early region 1A does not induce expression of the ewing sarcoma fusion product EWS-FLI1 in breast and ovarian cancer cell lines.
  • Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model.
  • Gene therapy by adenovirus-mediated vascular endothelial growth factor and angiopoietin-1 promotes perfusion of muscle flaps.
  • Replication of the herpes simplex virus type 1 RL1 mutant 1716 in primary neuronal cell cultures--possible relevance to use as a viral vector.
  • Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
  • Improved recombinant retroviral titers utilizing trichostatin A.
  • Construction of the recombinant retrovirus vector of HBV-S gene and it's expression in eukaryotic cells.
  • Lymphoid abnormalities in CD40 ligand transgenic mice suggest the need for tight regulation in gene therapy approaches to hyper immunoglobulin M (IgM) syndrome.
  • IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas.
  • In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.
  • Stem cell repopulation efficiency but not pool size is governed by p27(kip1).
  • NF-kappaB activation is inhibited in human pulmonary epithelial cells transfected with alpha-melanocyte-stimulating hormone vector.
  • Adenovirus mediated cytosine deaminase gene transduction and 5-fluorocytosine therapy sensitizes mouse prostate cancer cells to irradiation.
  • Introduction of the conventional method of DNA transfection by adenovirus vector
  • Mechanisms of tolerance induction by a gene-transferred peptide-IgG fusion protein expressed in B lineage cells.
  • Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression.
  • Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein-Barr virus-based episomal plasmid.
  • An enzymatic procedure for the purification of DNA restriction fragments without gel electrophoresis and ethidium bromide staining.
  • In vivo gene gun-mediated transduction into rat heart with Epstein-Barr virus-based episomal vectors.
  • Transcriptionally active drugs improve adenovirus vector performance in vitro and in vivo.
  • A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy.
  • In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells.
  • Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann-Pick disease.
  • A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens.
  • Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus.
  • The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors.
  • Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits.
  • Combining chromatin immunoprecipitation and DNA footprinting: a novel method to analyze protein-DNA interactions in vivo.
  • A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats.
  • Changes of phenotypes associated with activated Src by overexpressed PTPalpha in NIH3T3 cells
  • Elimination of a human T-cell region in staphylokinase by T-cell screening and computer modeling.
  • Adenovirus-mediated gene transfer in the ovine pituitary gland is associated with hypophysitis.
  • In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus.
  • Immunogenic regions of the GA733-2 tumour-associated antigen recognised by autoantibodies of patients with colorectal carcinoma.
  • Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells.
  • Recent advances in the diagnosis and treatment of colorectal cancers
  • Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection.
  • Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.
  • In vivo induction of tolerance by an Ig peptide is not affected by the deletion of FcR or a mutated IgG Fc fragment.
  • Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size.
  • Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity.
  • Expression of Reverse Cholesterol Transport Pathway Associated Protein Genes in Skeletal Muscle.
  • Ex vivo gene therapy with stromal cells transduced with a retroviral vector containing the BMP4 gene completely heals critical size calvarial defect in rats.
  • Single-chain antibody-based gene therapy: inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices.
  • Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
  • The molecular genetics of lentiviral vectors--current and future perspectives.
  • Lack of specificity of cell-surface protease targeting of a cytotoxic hyperfusogenic gibbon ape leukaemia virus envelope glycoprotein.
  • The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector.
  • Syngeneic fibroblasts transfected with a plasmid encoding interleukin-4 as non-viral vectors for anti-inflammatory gene therapy in collagen-induced arthritis.
  • C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgene.
  • TNF-alpha gene and proton radiotherapy in an orthotopic brain tumor model.
  • Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses.
  • Transgene expression in neonatal mouse inner ear explants mediated by first and advanced generation adenovirus vectors.
  • Expression of human VEGF(121) cDNA in mouse bone marrow stromal cells.
  • Evaluation of angiogenesis and side effects in ischemic rabbit hindlimbs after intramuscular injection of adenoviral vectors encoding VEGF and LacZ.
  • Evaluation of a porcine model for pulmonary gene transfer using a novel synthetic vector.
  • Regulated expression of insulin gene in non-beta cell
  • Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo.
  • Selective growth advantage of wild-type lymphocytes in X-linked SCID recipients.
  • Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis.
  • Construction of adenoviral vector encoding human VEGF(121) cDNA and its expression in vitro
  • Study on the in vivo killing activity of YCD/5-FC gene therapy system on K562B cells
  • Adenovirus-transduced lung as a portal for delivering alpha-galactosidase A into systemic circulation for Fabry disease.
  • Adenovirus induced acute hepatitis in non-human primates after liver-directed gene therapy.
  • Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells.
  • Inserting a nuclear targeting signal into a replication-competent Moloney murine leukemia virus affects viral export and is not sufficient for cell cycle-independent infection.
  • The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.
  • Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression.
  • Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid.
  • The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver.
  • Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt-1 vascular endothelial growth factor receptor.
  • Gene therapy by intrahepatic and intratumoral trafficking of p53-VP22 induces regression of liver tumors.
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  • Defective regulation of cholangiocyte Cl-/HCO3(-) and Na+/H+ exchanger activities in primary biliary cirrhosis.
  • Expression of a human beta-globin transgene in erythroid cells derived from retrovirally transduced transplantable human fetal liver and cord blood cells.
  • Therapeutic effects of astrocytes expressing both tyrosine hydroxylase and brain-derived neurotrophic factor on a rat model of Parkinson's disease.
  • Adenoviral and adeno-associated viral vector mediated gene transfer in the guinea pig cochlea.
  • Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors.
  • Pirfenidone effectively reverses experimental liver fibrosis.
  • Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system.
  • Efficient gene regulation by PPAR gamma and thiazolidinediones in skeletal muscle and heart.
  • Use of a chimeric adenovirus vector enhances BMP2 production and bone formation.
  • Regulation of mammalian liver methionine adenosyltransferase.
  • Liver as an ideal target for gene therapy: expression of CTLA4Ig by retroviral gene transfer.
  • Novel CNBP- and La-based translation control systems for mammalian cells.

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