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Rev Pneumol Clin. 2000 Sep;56(4):261-3.
[Dantrolene-induced pleurisy: a case report]

[Article in French]

Dohen F, Montagne V, Lelieur E.

Service de Pneumologie, Centre Hospitalier de Dunkerque 130, avenue Louis Herbeaux, B.P. 6.367, 59385 Dunkerque Cedex.

We report the case of a patient who developed dantrolene-induced pleurisy. Dantrolene (Dantrium) is a muscle relaxing agent used for the treatment of spastic neurological manifestations which has known liver toxicity. Lung toxicity is rarely reported. Six cases of dantrolene-induced pleurisy occurring after chronic administration (> 60 days) have been described in the literature. The pleurisy is associated with pleural and peripheral eosinophilia. Spontaneous regression a few days after withdrawal and radiological cure a few months later is the rule. The precise mechanism of this drug-induced pleural reaction remains unknown.


online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11033534&dopt=Abstract

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