Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene Fiale) and pharmaceutical products frequently used for combined therapy.

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Boll Chim Farm. 2002 Mar-Apr;141(2):122-7.
Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene Fiale) and pharmaceutical products frequently used for combined therapy.

Anacardio R, Perilli O, Bartolini S, Gentile MM, Mazzeo P, Carlucci G.

Research & Development, L'Aquila Research Centre, Dompe SpA, Italy.

Ketoprofen lysine salt (Artrosilene Fiale), a non steroidal anti-inflammatory agent, is frequently administered in association regimen with other drugs, such as steroidal anti-inflammatory, muscle relaxant, local anaesthetic and anti-spastic drugs or vitamins. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt (Artrosilene Fiale) and other injectable drugs frequently used in association. Physicochemical properties of ketoprofen lysine salt mixtures with different drugs, including colour, clarity, pH and drug content were observed or measured before and after (up to 3 hours) mixing at room temperature and under light protection. Results show that the association of Artrosilene Fiale with different drugs and vitamins does not cause, up to three hours f rom mixing, any significant variation in thephysicochemical parameters mentioned above, except for the association with Benexor B12 where a persistent phase separation occurs. In conclusion the results obtained demonstrated the physicochemical compatibility of Ketoprofen lysine salt (Artrosilene Fiale) with diverse drugs and vitamins, with a single exception.

online pharmacy ref. source: www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12135160&dopt=Abstract

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